DSO4204B connecting to software issue

Phil

Hi
I have the DSO4204B digital oscilloscope. I have an issue connecting on my main computer whereas it will connect on my laptop.
I've installed the keysight technologies drivers etc, and the DSO4000BC software. This works fine on my laptop windows 10, but not on my desktop windows 10.
Admittedly I have a lot on my desktop and use usb ports galore, but only the single use on the laptop.

The software is OK except for connection on my desktop. It won't connect to the Oscilloscope.
The oscilloscope is shown in the device manager as having no problems and working properly.

When I plug in the oscilloscop on the laptop and open the software it instantly connects
When I do the same on the desktop it does nothing other than open up the software without connecting.
Trying to connect stated the device is not connected when I connect to USB even though it is shown in the device manager as connected properly and working.

Any ideas?